Credible – Evidence Based

Dr. Johnson was granted several US patents related to the biological function of protocatechuate; a.k.a protocatechuic acid (PCA).  PCA is the primary metabolite from the dyes that make blueberries blue and cherries red.  When one eats those fruits the dyes are rapidly and completely metabolized into PCA and absorbed into your blood steam.  However, the amount possible by diet is far less than that which would have a significant biological effect.  For instance, one would have to eat 18 pounds of blueberries, at once to have a therapeutic effect on the body.

However, when isolated in the pure concentrated form, protocatechuate has certain beneficial biological properties as established by the supporting evidence published in the following patents.

As a result of several years research in the laboratory and the clinic, the formulation of A-Cosmetic was discovered.  This research included a two-year, four-phase study human study at Loma Linda Medical School looking for a pre-operative disinfectant.  The effectiveness of the A-Cosmetic formulation was established with the potential to disinfect human skin of many potential pathogens, including Propionibacterium acnes.  These discoveries have resulted in several United States patents (view specific patent claims below).

9,498,413

Antimicrobials and methods of use thereof for wound healing.  November 22, 2016.  This was the parent patent showing broad spectrum anti biotic properties and wound healing acceleration of protocatechuate.

9,925,152

Antimicrobials and methods of use thereof for wound healing. March 27, 2018.  This was a continuation of the above parent application that added the other secondary metabolite 2,4,6 trihydroxybenzaldehyde to the broad spectrum antibiotic function.  In addition the evidence supported the responses with increased collagen proliferation (i.e. wrinkle treatment) and reduction in scar formation.

10,004,705

Antimicrobials and the methods of use. 7/26/2018. This patent included the metabolites of protocatechuic acid and 2,4,6 trihydroxybenzaldehyde for the destruction of biofilms of MRSA and Pseudomonas when PCA was applied to metal, cloth and ceramic.

10,004, 706

Antimicrobials and the methods of use.  6/26/2018.  This was an expansion of 10,004,705 application’s claims.

10,016,380

Antimicrobials and the methods of use. 7/10/2018.  This patent expanded the formulation for treatment of implants to include protocatechuic acid, 70% isopropyl alcohol, propylene glycol, and an essential oil.

10,034,842

Antimicrobials and methods of use thereof for wound healing.  7/31/2018.  This patent includes the chemical formulation of 10,016,380 for medical and surgical implants, dental implants and instrumentation.  The later for spaying or soaking in solution.

10,143,670

 Antimicrobials and methods of use thereof.  December 4, 2018.  This patent secures the use of PCA to  coat a bandage or dressing at time or treatment and or a commercial preparation for as stated in claim #22 if a wound is a burn, skin break, bone break, muscle tear, puncture, surgical incision site, microdermabrasion site, skin graft site, a wound associated with diabetes, a bed sore, a pressure sore, skin defoliation, or a laceration, and wherein the protocatechuic acid becomes activated by contact with moisture from the wound.

10,265,285

Antimicrobials and methods of use thereof.  April 23, 2019.  This patent is an extension of prior claims that specifically cite PCA in a formulation that has antibacterial effect upon Propionibacterium acnes.  This is the same formulation used in A-cosmetic.

The claims granted for US 10, 265, 285 are highlighted.  The formulation contents are highlighted; protocatechuic acid, 70% isopropyl alcohol, propylene glycol and an essential oil.

Listing of the claims as they actually appear on the patient related to A-Cosmetic product.

12. A method for inhibiting P. acnes growth on mammalian skin tissue, comprising: applying a liquid composition to the skin tissue, the composition comprising  about 10% or more of protocatechuic acid (PCA), and a liquid carrier comprising 70% to 91% grade isopropyl alcohol, wherein commensal microorganisms are preserved.

13. The method according to claim 12, wherein the PCA is present at a concentration of from about 10% to about 50% by weight of the composition.

14. The method according to claim 12, wherein the liquid composition further comprises propylene glycol and an essential oil, wherein the components all possess anti-bacterial and skin penetration properties.

15. The method according to claim 12, wherein the amount of PCA is from about 10% to about 30% by weight of the composition.

16. The method according to claim 12, wherein the liquid composition comprises: about 1% to about 15% propylene glycol and about 1% to about 5% of an essential oil, by weight of the composition.

17-20. (Cancelled) 

21. The method according to claim 12, wherein the PCA is administered in an amount of about 60 mg/kg.

22. The method according to claim 12, wherein the mammal is a human.

23. The method according to claim 12, wherein the composition comprises about 10% PCA.

24. The method according to claim 12, wherein the composition comprises about 17% PCA.

25. The method according to claim 12, wherein the composition comprises about 20% PCA.

26. The method according to claim 12, wherein the liquid carrier comprises 70% grade isopropyl alcohol.

27. The method according to claim 12, wherein the liquid carrier comprises 91% grade isopropyl alcohol.